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Molecular structure

2D reference
Sequence-derived 2D chemical structure of Alpha-Synuclein (1–140), E46K, 140 amino-acid residues. K46 is highlighted in gold.
E46K substitution · Lys46View full size
Reference sequence140 residues
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

Sequence-derived chemical connectivity. Free N terminus and C-terminal acid; no specific 3D fold is implied.

PL-SYN-003 Synuclein peptides & proteins

Alpha-Synuclein (1–140), E46K

$24.99

Human alpha-synuclein E46K variant, comprising 140 amino acids for comparative laboratory studies of protein conformation and sequence-dependent molecular association.

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SKU: PL-SYN-003 Category:

Technical identity

Catalog ID
PL-SYN-003
Construct
Human alpha-synuclein 1–140, E46K
Reference sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Calculated reference mass
14459.21 Da — calculated average mass of the unmodified free-acid chain; not a measured result. Tags, termini, modifications, counterions and disulfides change the actual mass.
Reference modifications
E46K substitution

Reference identity: UniProt P37840. Calculated mass describes the reference chain and does not replace a measured lot result.

Documentation

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For qualified organizational in vitro research only. Purchasing access is available to approved research organizations.

Description

Alpha-Synuclein (1–140), E46K is a 140-amino-acid protein representing the complete 140-residue human alpha-synuclein sequence. Alpha-synuclein is encoded by the SNCA gene; the reference sequence is recorded as UniProt P37840. Sequence reference: UniProt P37840.

Research context

This chain includes the N-terminal region at parent-sequence residues 1–60; the central non-amyloid-beta component (NAC) region at parent-sequence residues 61–95; the C-terminal region at parent-sequence residues 96–140. The intact sequence brings these regions together in one reference chain for studies of their combined structural and molecular interactions. The E46K variant replaces glutamic acid with lysine at position 46; numbering refers to the complete 140-residue protein.

Alpha-synuclein is a neuronal protein associated with synaptic vesicle biology. Its molecular association and assembly into amyloid structures are central topics in Parkinson’s disease and synucleinopathy research. Studies distinguish the functions of the N-terminal, NAC, and C-terminal regions and examine how substitutions or truncations change their relationships within the protein. Research reference.

Research applications

  • Comparing a defined sequence variant with unmodified full-length alpha-synuclein.
  • Mapping regional contributions to protein association and conformational behavior.
  • Biophysical studies of alpha-synuclein-derived chains in defined in vitro systems.

Molecular identity

  • Catalog ID: PL-SYN-003
  • Product type: Protein
  • Reference species: Human (Homo sapiens)
  • Sequence length: 140 amino acids
  • Reference region: Human alpha-synuclein 1–140, E46K
  • Calculated average molecular mass: 14,459.21 Da for the free-acid reference chain with the stated substitution
  • Sequence modification: E46K substitution

Reference sequence

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKKGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

For in vitro laboratory research only. Not for human or animal administration.

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