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Molecular structure

2D reference
Sequence-derived 2D chemical structure of Tau 2N4R (1–441), V337M, 441 amino-acid residues. M337 is highlighted in gold.
V337M substitution · Met337View full size
Reference sequence441 residues
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

Sequence-derived chemical connectivity. Free N terminus and C-terminal acid; no specific 3D fold is implied.

PL-TAU-005 Tau peptides & proteins

Tau 2N4R (1–441), V337M

$54.99

Human tau 2N4R V337M variant, comprising 441 amino acids with residue numbering matched to the 441-residue isoform for tau sequence and assembly research.

In stock

SKU: PL-TAU-005 Category:

Technical identity

Catalog ID
PL-TAU-005
Construct
Human tau 2N4R 1–441, V337M
Reference sequence
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Calculated reference mass
45881.97 Da — calculated average mass of the unmodified free-acid chain; not a measured result. Tags, termini, modifications, counterions and disulfides change the actual mass.
Reference modifications
V337M substitution

Reference identity: UniProt P10636-8. Calculated mass describes the reference chain and does not replace a measured lot result.

Documentation

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For qualified organizational in vitro research only. Purchasing access is available to approved research organizations.

Description

Tau 2N4R (1–441), V337M is a 441-amino-acid protein corresponding to the complete human tau 2N4R isoform. All residue numbers refer to the 441-residue 2N4R isoform, UniProt P10636-8. The designation 2N4R identifies two N-terminal inserts and four microtubule-binding repeats in the parent protein. Sequence reference: UniProt P10636-8.

Research context

The complete chain includes the N-terminal region, the proline-rich region, all four repeat regions, and the C-terminal extension. This full-sequence context allows comparisons with isolated repeat segments and terminal fragments. The sequence includes PHF6* (VQIINK, residues 275–280) and PHF6 (VQIVYK, residues 306–311), motifs examined in research on tau amyloid assembly. The V337M substitution replaces valine with methionine at 2N4R position 337, providing a defined variant for comparison with the unmodified 2N4R sequence.

Tau is a microtubule-associated protein encoded by MAPT. The parent protein contributes to microtubule assembly and stability, while tau self-association and amyloid formation are studied in Alzheimer’s disease and other tauopathies. Sequence-defined proteins and fragments help distinguish the roles of individual regions from the behavior of the complete isoform. Research reference.

Research applications

  • Comparing defined tau 2N4R sequences, fragments, and substitution variants.
  • Mapping regional contributions to tau conformation and molecular association.
  • Sequence-focused investigation of tau assembly in in vitro research systems.

Molecular identity

  • Catalog ID: PL-TAU-005
  • Product type: Protein
  • Reference species: Human (Homo sapiens)
  • Sequence length: 441 amino acids
  • Reference region: Human tau 2N4R 1–441, V337M
  • Calculated average molecular mass: 45,881.97 Da for the free-acid reference chain with the stated substitution
  • Sequence modification: V337M substitution

Reference sequence

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQMEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

For in vitro laboratory research only. Not for human or animal administration.

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