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Molecular structure

2D reference
Sequence-derived 2D chemical structure of Alpha-Synuclein (1–140), A53T, 140 amino-acid residues. T53 is highlighted in gold.
A53T substitution · Thr53View full size
Reference sequence140 residues
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

Sequence-derived chemical connectivity. Free N terminus and C-terminal acid; no specific 3D fold is implied.

PL-SYN-004 Synuclein peptides & proteins

Alpha-Synuclein (1–140), A53T

$49.99

Human alpha-synuclein A53T variant, comprising 140 amino acids for comparative laboratory studies of protein conformation and sequence-dependent molecular association.

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SKU: PL-SYN-004 Category:

Technical identity

Catalog ID
PL-SYN-004
Construct
Human alpha-synuclein 1–140, A53T
Reference sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Calculated reference mass
14490.18 Da — calculated average mass of the unmodified free-acid chain; not a measured result. Tags, termini, modifications, counterions and disulfides change the actual mass.
Reference modifications
A53T substitution

Reference identity: UniProt P37840. Calculated mass describes the reference chain and does not replace a measured lot result.

Documentation

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For qualified organizational in vitro research only. Purchasing access is available to approved research organizations.

Description

Alpha-Synuclein (1–140), A53T is a 140-amino-acid protein representing the complete 140-residue human alpha-synuclein sequence. Alpha-synuclein is encoded by the SNCA gene; the reference sequence is recorded as UniProt P37840. Sequence reference: UniProt P37840.

Research context

This chain includes the N-terminal region at parent-sequence residues 1–60; the central non-amyloid-beta component (NAC) region at parent-sequence residues 61–95; the C-terminal region at parent-sequence residues 96–140. The intact sequence brings these regions together in one reference chain for studies of their combined structural and molecular interactions. The A53T variant replaces alanine with threonine at position 53; numbering refers to the complete 140-residue protein.

Alpha-synuclein is a neuronal protein associated with synaptic vesicle biology. Its molecular association and assembly into amyloid structures are central topics in Parkinson’s disease and synucleinopathy research. Studies distinguish the functions of the N-terminal, NAC, and C-terminal regions and examine how substitutions or truncations change their relationships within the protein. Research reference.

Research applications

  • Comparing a defined sequence variant with unmodified full-length alpha-synuclein.
  • Mapping regional contributions to protein association and conformational behavior.
  • Biophysical studies of alpha-synuclein-derived chains in defined in vitro systems.

Molecular identity

  • Catalog ID: PL-SYN-004
  • Product type: Protein
  • Reference species: Human (Homo sapiens)
  • Sequence length: 140 amino acids
  • Reference region: Human alpha-synuclein 1–140, A53T
  • Calculated average molecular mass: 14,490.18 Da for the free-acid reference chain with the stated substitution
  • Sequence modification: A53T substitution

Reference sequence

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

For in vitro laboratory research only. Not for human or animal administration.

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