Description
APP770 fragment (751–770) is a 20-amino-acid peptide fragment corresponding to residues 751–770 of human amyloid precursor protein isoform APP770. Numbering follows the 770-residue reference sequence in UniProt P05067, allowing this fragment to be aligned directly with other APP-derived materials. Sequence reference: UniProt P05067.
Research context
This fragment maps to the C-terminal intracellular portion of APP770. The 751–770 sequence defines a particular part of the APP tail for comparisons with longer C-terminal chains and overlapping fragments in region-specific molecular interaction studies. It retains the YENPTY motif at APP770 residues 757–762, a region involved in interactions with intracellular adaptor proteins.
APP is a membrane protein whose proteolytic processing produces multiple extracellular and C-terminal fragments, including amyloid-beta peptides. APP research examines how local sequence, cleavage boundaries, and interactions within the C-terminal tail relate to protein processing and signaling. Individual fragments provide defined sequences for studying selected parts of this broader molecular system. Research reference.
Research applications
- Mapping defined APP770 sequence regions and fragment boundaries.
- Comparative characterization of overlapping APP-derived chains.
- Investigating region-specific molecular recognition and protein-interaction sequences.
Molecular identity
- Catalog ID: PL-APP-014
- Product type: Peptide
- Reference species: Human (Homo sapiens)
- Sequence length: 20 amino acids
- Reference region: Human APP canonical 770-residue isoform, residues 751–770
- Calculated average molecular mass: 2,525.79 Da for the unmodified free-acid reference chain
- Sequence modification: Unmodified reference sequence
Reference sequence
KMQQNGYENPTYKFFEQMQN
For in vitro laboratory research only. Not for human or animal administration.