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Molecular structure

2D reference
Sequence-derived 2D chemical structure of Tau 2N4R fragment (275–280), 6 amino-acid residues.
Linear reference chainView full size
Reference sequence6 residues
VQIINK

Sequence-derived chemical connectivity. Free N terminus and C-terminal acid; no specific 3D fold is implied.

PL-TAU-012 Tau peptides & proteins

Tau 2N4R fragment (275–280)

$449.99

Human tau 2N4R fragment (275–280), comprising 6 amino acids with residue numbering matched to the 441-residue isoform for tau sequence and assembly research.

In stock

SKU: PL-TAU-012 Category:

Technical identity

Catalog ID
PL-TAU-012
Construct
Human tau 2N4R residues 275–280; numbering refers to 441-residue isoform
Reference sequence
VQIINK
Calculated reference mass
713.88 Da — calculated average mass of the unmodified free-acid chain; not a measured result. Tags, termini, modifications, counterions and disulfides change the actual mass.
Reference modifications
Unmodified reference chain

Reference identity: UniProt P10636-8. Calculated mass describes the reference chain and does not replace a measured lot result.

Documentation

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For qualified organizational in vitro research only. Purchasing access is available to approved research organizations.

Description

Tau 2N4R fragment (275–280) is a 6-amino-acid peptide fragment spanning residues 275–280 of human tau 2N4R. All residue numbers refer to the 441-residue 2N4R isoform, UniProt P10636-8. The designation 2N4R identifies two N-terminal inserts and four microtubule-binding repeats in the parent protein. Sequence reference: UniProt P10636-8.

Research context

The fragment covers R2 residues 275–280. Its defined sequence boundaries provide a focused region for studies comparing tau repeat segments and longer chains. The sequence includes PHF6* (VQIINK, residues 275–280), a motif examined in research on tau amyloid assembly.

Tau is a microtubule-associated protein encoded by MAPT. The parent protein contributes to microtubule assembly and stability, while tau self-association and amyloid formation are studied in Alzheimer’s disease and other tauopathies. Sequence-defined proteins and fragments help distinguish the roles of individual regions from the behavior of the complete isoform. Research reference.

Research applications

  • Comparing defined tau 2N4R sequences, fragments, and substitution variants.
  • Mapping regional contributions to tau conformation and molecular association.
  • Sequence-focused investigation of tau assembly in in vitro research systems.

Molecular identity

  • Catalog ID: PL-TAU-012
  • Product type: Peptide
  • Reference species: Human (Homo sapiens)
  • Sequence length: 6 amino acids
  • Reference region: Human tau 2N4R residues 275–280; numbering refers to 441-residue isoform
  • Calculated average molecular mass: 713.88 Da for the unmodified free-acid reference chain
  • Sequence modification: Unmodified reference sequence

Reference sequence

VQIINK

For in vitro laboratory research only. Not for human or animal administration.

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